Part:BBa_K3833003

Fibronectin Binding Domain

Fibronectin is a glycoprotein found in a cell's extracellular matrix. The glycoprotein plays a role in forming the matrix structure as well as in cell proliferation. Fibronectin has been found to interact with collagen and certain binding domains that promote aggregation of fibronectin [1]. The documented part is meant for insertion into the triple helical structure of Scl2 (Part BBa_K3833000) in order to allow for cell adhesion to hydrogels containing the Scl2. The fibronectin binding domain documented here is GLAGQRGIVGLPGQRGER.

Sources.
[1] An, B., Abbonante, V., Yigit, S., Balduini, A., Kaplan, D. L., & Brodsky, B. (2014). Definition of the native and denatured type II collagen binding site for fibronectin using a recombinant collagen system. Journal of Biological Chemistry, 289(8), 4941-4951.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]